Includes bibliographical references and index
|Series||In focus, In focus (Oxford, England)|
|LC Classifications||QP624 .N45 1994|
|The Physical Object|
|Pagination||ix, 108 p. :|
|Number of Pages||108|
|LC Control Number||93036757|
DNA Structure and Function, a timely and comprehensive resource, is intended for any student or scientist interested in DNA structure and its biological implications. The book provides a simple yet comprehensive introduction to nearly all aspects of DNA structure. It also explains current ideas on the biological significance of classic and alternative DNA conformations. To aid novices, Principles of Nucleic Acid Structure includes an introduction to technical lingo used to describe nucleic acid structure and conformations (roll, slide, twist, buckle, etc.). This completely updated edition features expanded coverage of the latest advances relevant to recognition of DNA and RNA by small molecules and proteins. DNA replication occurs when the DNA strands “unzip,” and the original strands of DNA serve as a template for new nucleotides to join and form a new strand. Summary During DNA replication, the DNA helix unwinds and the two single strands of DNA then each . Many DNA-binding proteins possessing disparate functions have been shown to bend their DNA recognition sites (28, 44, 45). A distinction can be made, however, between those proteins whose primary, if not sole, function is to bend DNA, and those proteins that happen to bend DNA in the process of carrying out their distinct primary by:
It is a popular science book written by well known experts in the field of DNA structure. It is concentrated on fine features of the DNA molecular structure, which play very important role in DNA functioning. Such issues as DNA bending and DNA winding in the nucleosome particles is covered in significant details. Many HMG-domain proteins recognize altered DNA structures such as four-way junctions and cisplatin-modified DNA5, but until now the molecular basis for this recognition Cited by: We also hypothesize that for each of the recognition sequences, an ordered DNA barrel structure forms only on one particular (n,m) tube, resulting in their purification by IEX. Figure 2: DNA Cited by: An example of inhibitory RNA aptamers binding the NF-kappaB transcription factor by molecular mimicry of the normal DNA target from the Nucleic Acid Structure and Recognition Lab led by Jim Maher, Ph.D., at Mayo Clinic. The research laboratory of Jim Maher, Ph.D., studies the nucleic acids DNA and.
A genetics book, by the one of the co-discoverers of the double helix structure of DNA. There's a few chapters about the science, about the history of genetics and then a variety of topics, genetically modified foods and the controversy, DNA evidence in solving crimes, genetic diseases, ancient racial ancestry, ethical questions, bio-tech politics/5(). In practice, DNA recognition by proteins effectively spans a continuum from completely digital to completely analogue with many proteins utilizing both modes. For both modes of recognition, the DNA double helix differs from, and is arguably more effective than, the RNA double by: Transcription factors are classified in families according to the structure of their DNA-binding domain. eukaryotic transcription factors as an introduction to the specific chapters dealing with the structure and function of plant transcription factors in this book. including recognition of a narrowed minor groove of DNA . DNA STRUCTURE DNA Is Composed of Polynucleotide Chains The most important feature of DNA is that it is usually composed of two polynucleotide chainstwisted around each other in the form of a double helix (Figure ). The upper part of the ﬁgure (a) presents the structure of the double helix shown in a schematic form. Note that ifFile Size: 1MB.